Type I IFN receptor controls B cell expression of nucleic acid sensing toll-like receptors and autoantibody production in a murine model of lupus
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چکیده
Type I IFN receptor controls B cell expression of nucleic acid sensing toll-like receptors and autoantibody production in a murine model of lupus Arthritis Research & Therapy 2009, 11:R112 doi:10.1186/ar2771 Donna L Thibault ([email protected]) Kareem L Graham ([email protected]) Lowen Y Lee ([email protected]) Imelda Balboni ([email protected]) Paul J Hertzog ([email protected]) Paul J Utz ([email protected])
منابع مشابه
Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus
INTRODUCTION Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of high-titer IgG autoantibodies directed against nuclear autoantigens. Type I interferon (IFN-I) has been shown to play a pathogenic role in this disease. In the current study, we characterized the role of the IFNAR2 chain of the type I IFN (IFN-I) receptor in the targeting of nuclei...
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تاریخ انتشار 2009